Review of Lysosome-Targeting Chimeras for Overcoming Cancer Drug Resistance

A 2.0 MB PDF review article authored by Huixin Mao, last updated on 2026-05-28. The document systematically compares lysosome-targeting chimeras (LYTACs) to PROTACs, summarizes design principles, and discusses applications for overcoming resistance to chemotherapy, targeted therapy, and immunotherapy.

Use Cases

• Literature review on lysosome-targeting chimeras (LYTACs) based on the systematic comparison of mechanisms and design principles described.
• Identifying therapeutic opportunities for overcoming cancer drug resistance based on the discussion of LYTAC applications against chemotherapy, targeted therapy, and immunotherapy resistance.
• Analyzing translational bottlenecks in targeted protein degradation based on the critical analysis of delivery efficiency, receptor heterogeneity, and pharmacokinetic limitations.

Strengths

• File size is precisely 2.0 MB, indicating a contained document.
• Released under a permissive CC-BY-4.0 license, allowing for broad reuse and sharing.
• Last update timestamp is explicitly provided as 2026-05-28 04:51:08.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is a single PDF review article, not a primary data collection.

Provenance

Source

figshare

Collection Method

Authored review article.

Freshness

Last updated 2026-05-28 04:51:08; freshness should be verified.