Macrophage Autophagy and TARM1 Degradation Data in Acute Kidney Injury Mouse Models

Xiao-Rong Huang published experimental data on figshare in 2026 investigating the protective role of macrophage autophagy in acute kidney injury. The dataset includes results from mouse models with macrophage-specific autophagy deficiency, adoptive transfer experiments, and in vitro studies on bone marrow-derived macrophages. It contains measurements of serum creatinine, renal tubule injury scores, macrophage infiltration, and inflammatory factor expression.

Use Cases

• Analyze the correlation between macrophage autophagy deficiency and serum creatinine levels based on described mouse model data.
• Model inflammatory response pathways based on pro-inflammatory cytokine expression data from bone marrow-derived macrophages.
• Investigate protein degradation mechanisms based on data describing TARM1 ubiquitination and autophagy-dependent degradation.

Strengths

• Dataset is 62.8 MB in size, indicating a substantial volume of supporting data.
• Includes data from multiple experimental approaches: in vivo mouse models, adoptive transfer, and in vitro cell studies.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

Xiao-Rong Huang

Collection Method

Experimental data from mouse models of acute kidney injury induced by LPS or ischemia-reperfusion, and in vitro studies on macrophages.

Freshness

Last updated 2026-06-02 11:42:34; freshness should be verified.