Macrophage membrane-encapsulated liposomes of protopanaxadiol-type doxorubicin hydrochlori

A dataset from figshare details the preparation and characterization of macrophage membrane-encapsulated protopanaxadiol-type doxorubicin hydrochloride liposomes (DOX-(PPD)-LIP@M). It includes measurements of particle size (149.21 nm), polydispersity coefficient (0.22), zeta potential (27.5 mV), encapsulation rate (89.71%), and drug loading (7.28%), along with results from in vitro and in vivo studies. The data was authored by Xinxin Bai and last updated in May 2026.

Use Cases

• Optimizing liposome formulation parameters based on particle size, polydispersity, and encapsulation efficiency data
• Evaluating drug stability and in vitro release profiles for novel nanocarrier systems
• Assessing in vivo anti-tumor efficacy and cardiac safety of targeted drug delivery platforms

Strengths

• Includes specific, reported metrics for key formulation parameters (e.g., particle size 149.21 nm, encapsulation rate 89.71%)
• Describes both in vitro cellular assays on 4T1 tumor cells and in vivo pharmacodynamic studies
• Data is associated with a published, peer-reviewed research methodology (Box-Behnken design-response surface methodology)

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Data likely originates from laboratory experiments optimizing liposome preparation and conducting cellular and animal studies.

Freshness

Last updated 2026-05-11 07:17:42; freshness should be verified