Majoon Ushba: Pre-clinical Data on Psoriasis Treatment via IL-17A/JAK-2-STAT-3 Pathway

A research dataset containing pre-clinical efficacy data for the Unani polyherbal formulation Majoon Ushba against psoriasis. The data includes in vitro results from HaCaT cell studies and in vivo results from an imiquimod-induced mouse model, alongside in-silico docking analysis of phytoconstituents. The dataset was authored by Arulkumaran Rithvik and last updated on 2026-04-28.

Use Cases

• Validate the role of the JAK-2-STAT-3 signaling axis in keratinocyte ferroptosis based on the described experimental results.
• Assess the binding affinity of herbal phytoconstituents to IL-17RA and STAT-3 targets based on the in-silico docking analysis.
• Compare the efficacy of Majoon Ushba in reducing serum cytokine levels (IL-17A, IL-23, IFN-γ) against other treatments.
• Investigate the relationship between GPX4 expression and lipid peroxidation regulation in psoriatic inflammation models.

Strengths

• Dataset is 52.4 MB in size, containing detailed research documentation.
• The study combines in vitro, in vivo, and in-silico analysis methods as described.
• Data is shared under a CC-BY-4.0 license, permitting broad reuse.

Limitations

• The primary data format is PDF, which may require extraction for computational analysis.
• Row count and column-level metadata are unknown, limiting suitability assessment.
• The dataset's description is detailed but does not specify the raw data structure or sample size.

Provenance

Source

figshare

Collection Method

Experimental research involving cell culture, animal models, and computational docking.

Freshness

Last updated 2026-04-28 09:15:37.