Mapping of the hSOX10 Proximal Protein Interactome in Human Melanoma

847 candidate protein interactors for the transcription factor SOX10 were identified in melanoma cells using proximity-dependent biotinylation and mass spectrometry. The dataset was refined to 124 biologically relevant candidates by Catherine M. Newsom-Stewart and published on figshare in 2026. It provides a high-confidence resource for investigating SOX10-associated regulatory networks and therapeutic vulnerabilities in melanoma.

Use Cases

• Prioritizing candidate drug targets based on the 124 biologically relevant SOX10 interactors.
• Hypothesizing about melanoma therapeutic vulnerabilities based on enriched pathways like chromatin-modifying complexes.
• Studying transcriptional regulation in cancer by analyzing the network of transcriptional regulators and cofactors identified.

Strengths

• Identifies 847 melanoma-enriched candidate hSOX10 interactors.
• Refines the list to 180 high-confidence candidates using stringent statistical filtering and contaminant profiling.
• Further prioritizes 124 biologically relevant candidates using orthogonal criteria like transcriptomic coexpression and genomic co-occurrence.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is specific to A375 melanoma cell lines; generalizability to other models may be limited.

Provenance

Source

figshare

Collection Method

MiniTurbo (mT) proximity-dependent biotinylation coupled with mass spectrometry in A375 melanoma cells.

Freshness

Last updated 2026-05-12 09:17:07