hSOX10 Proximal Protein Interactome in Human Melanoma Cells

A high-confidence resource mapping 847 candidate and 124 biologically relevant proximal protein interactors of the transcription factor SOX10 in human melanoma. The dataset was generated by Catherine M. Newsom-Stewart using miniTurbo proximity-dependent biotinylation coupled with mass spectrometry in A375 melanoma cells. It was last updated on May 12, 2026, and is provided as a 375.8 KB XLSX file.

Use Cases

• Prioritizing candidate proteins for functional validation based on the evidence-based prioritization framework.
• Investigating SOX10-associated regulatory networks and chromatin-modifying complexes mentioned in the description.
• Identifying potential therapeutic vulnerabilities in melanoma based on the high-confidence interactor list.

Strengths

• Identifies 847 melanoma-enriched candidate interactors and refines the list to 180 high-confidence and 124 biologically relevant candidates.
• Uses a stringent methodology including stable lines expressing tagged proteins at near-endogenous levels and statistical filtering.
• Integrates orthogonal biological relevance criteria such as transcriptomic coexpression and genomic co-occurrence.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (375.8 KB), indicating a limited scope focused on a specific protein interaction mapping.

Provenance

Source

figshare

Collection Method

Generated using miniTurbo proximity-dependent biotinylation coupled with mass spectrometry in A375 melanoma cells.

Freshness

Last updated 2026-05-12 09:17:05; freshness should be verified.