DYRK1A-Leucettinib-21 Interaction Network in Rat Brain

A 3.2 MB dataset from figshare, last updated April 15, 2026, authored by Emmanuel Deau. It details protein targets identified through four complementary affinity chromatography methods applied to rat brain tissue. The data likely contains interactions of the kinase inhibitor Leucettinib-21 with DYRK1A and other proteins.

Use Cases

• Validate known drug-protein interactions based on the described affinity chromatography methods.
• Identify novel kinase and non-kinase targets of Leucettinib-21 based on the reported experimental results.
• Investigate potential new binding partners of the DYRK1A kinase as suggested by the study's findings.
• Analyze cellular pathways and mechanisms potentially modulated by Leucettinib-21 based on the identified protein network.

Strengths

• Data generated using four complementary experimental approaches, as described in the study.
• File size is 3.2 MB, indicating a manageable download and analysis scale.
• Dataset is licensed under CC-BY-NC-4.0, specifying clear terms for non-commercial reuse.

Limitations

• Row count and column definitions are unknown, limiting suitability assessment for specific analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is derived from rat brain tissue, which may limit direct translation to human biology.

Provenance

Source

figshare, authored by Emmanuel Deau.

Collection Method

Generated via four affinity chromatography-based approaches on rat brain tissue, as described.

Freshness

Last updated 2026-04-15 19:15:13; freshness should be verified.