MSCP: Integrated Catalog of 15,964 Mass Spectrometry-Detected Cancer Proteins

An integrated database assembled from 27 large-scale cancer proteomics sources by Yuanyu Huang, last updated in May 2026. It provides a unified catalog of 15,964 MS-supported human proteins harmonized to UniProtKB-Swiss-Prot. The resource spans human tumor cohorts, cancer cell lines, and patient-derived xenograft models.

Use Cases

• Benchmarking cancer-context protein detection against reference proteomes based on the unified FDR-controlled catalog.
• Planning targeted proteomics assays based on the provenance-aware, cohort- and model-specific querying capabilities.
• Investigating functional pathways like immune response or chromatin regulation based on the GO and Reactome enrichment of newly identified proteins.
• Verifying protein identifications using orthogonal synthetic peptide data based on the described concordant precursor and fragment-ion patterns.

Strengths

• Integrated data from 27 distinct large-scale cancer proteomics sources.
• Unified catalog of 15,964 human proteins with harmonized UniProtKB identifiers.
• Identified 525 proteins newly supported by MS evidence in a cancer context.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (37.0 KB), indicating it is likely a catalog or index rather than containing raw spectral data.

Provenance

Source

figshare, author Yuanyu Huang.

Collection Method

Assembled and harmonized from 27 large-scale cancer proteomics sources.

Time Range

Temporal coverage of the source studies is not specified.

Freshness

Last updated 2026-05-01 14:34:53; freshness should be verified.

Geography

Spatial coverage is not specified; data includes human tumor cohorts, cell lines, and PDX models.