MSCP: Integrated Catalog of 15,964 Mass Spectrometry-Detected Cancer Proteins

15,964 human proteins detected by mass spectrometry across 27 cancer proteomics sources are unified in this resource. The MSCP database, created by Yuanyu Huang and updated in May 2026, harmonizes evidence from tumor cohorts, cell lines, and patient-derived xenografts to a UniProtKB reference. It identifies 525 proteins newly supported by MS evidence in a cancer context, enabling standardized comparisons for translational studies.

Use Cases

• Benchmarking cancer protein detection evidence against reference proteomes based on the unified FDR-controlled catalog.
• Planning downstream targeted assays based on the provenance-aware, cohort-specific querying capability.
• Investigating functional pathways like chromatin regulation or immune processes based on the enrichment analysis of newly identified proteins.
• Resolving chromosome-level evidence inconsistencies for specific proteins using the integrated cancer-context data.

Strengths

• Integrates protein identifications from 27 distinct large-scale cancer proteomics sources.
• Provides a unified catalog of 15,964 MS-supported human proteins with harmonized UniProtKB identifiers.
• Identifies 525 proteins newly supported by mass spectrometry evidence in an integrated cancer context.
• Includes orthogonal verification using synthetic unique peptides for representative newly identified proteins.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale statistical tasks.
• The dataset is very small (12.9 KB), suggesting it may be a summary or metadata file rather than the full underlying data.

Provenance

Source

Assembled from 27 large-scale cancer proteomics sources, including human tumor cohorts, cancer cell lines, and patient-derived xenograft models.

Collection Method

Protein identifications were harmonized to UniProtKB-Swiss-Prot and integrated under FDR-controlled identification outputs.

Time Range

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Freshness

Last updated 2026-05-01 14:34:52; freshness should be verified.

Geography

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