Maternal Chikungunya virus infection and pregnancy outcomes: a global systematic review an

A global systematic review and meta-analysis of 57 observational studies on Chikungunya virus infection during pregnancy, published up to October 20, 2025. The study, authored by Yan Guo and registered in PROSPERO, quantifies vertical transmission rates and adverse perinatal outcomes. It was last updated on April 22, 2026.

Use Cases

• Modeling vertical transmission risk based on gestational age gradients described in the meta-analysis
• Assessing the association between maternal CHIKV infection and specific adverse outcomes like abnormal fetal heart rate or delayed neurodevelopment
• Informing public health intervention strategies based on pooled rates of neonatal mortality and morbidity
• Benchmarking local clinical outcomes against the global meta-analysis findings for stillbirth and neonatal complications

Strengths

• Evidence synthesis is based on 57 observational studies for qualitative review, with 27 studies included in meta-analyses
• Reports specific pooled rates, including an 18.1% vertical transmission rate and an 11.3% rate of adverse pregnancy outcomes
• Provides odds ratios from comparative studies, such as a 2.28-fold higher risk of adverse perinatal outcomes associated with maternal infection

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Data is presented in a PDF format (8.2 MB), which may require extraction for computational analysis

Provenance

Source

Yan Guo

Collection Method

Systematic review and meta-analysis of published observational studies, prospectively registered in PROSPERO (CRD420251164423)

Time Range

Studies published up to October 20, 2025

Freshness

Last updated 2026-04-22 02:47:37; freshness should be verified

Geography

Global