Meijer et al: Histology Data for Layer 6b and Sleep/Wake States

Meijer et al's 1.65 GB dataset contains histological images and cell density analyses investigating the role of brain layer 6b in sleep and wakefulness. The data includes TIFF and PNG images of brain sections and a Prism file comparing Drd1a-Cre positive cell densities across cortical layers. This resource supports research into how the orexin system and specific neuronal populations mediate state-dependent brain activity.

Use Cases

• Quantifying Drd1a-Cre positive cell densities across cortical layers using the provided Prism analysis file.
• Analyzing high-resolution histological brain section images (TIFFs/PNGs) for anatomical studies.
• Correlating histological markers (Drd1a, Cplx3, Tbr1) with brain state changes described in the associated research.
• Validating image analysis pipelines for cell counting in specific brain regions like layer 6b.

Strengths

• Contains a substantial 1.65 GB volume of high-resolution histological image files.
• Includes a structured analysis file (Prism format) for direct comparison of cell densities.
• Released under a permissive CC-BY-4.0 license, facilitating reuse and sharing.
• Cross-platform presence on figshare suggests established importance and accessibility.

Limitations

• Column names and row counts for any tabular data are not explicitly provided in the metadata.
• The dataset description is sparse, lacking detailed documentation on experimental protocols or image annotations.
• The listed update date (2026-03-22) is in the future, creating a conflict regarding data freshness.

Provenance

Source

Elise Meijer

Collection Method

Likely generated from histological imaging and cell density quantification of brain tissue.

Time Range

null

Freshness

Last updated date is listed as 2026-03-22, which is inconsistent and cannot be verified.

Geography

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