Membrane Proteome Remodeling in Female APP/PS1 Mice Following M1 Receptor Modulation

6.8 MB of proteomic data from a study of Alzheimer's disease in a mouse model. The dataset, uploaded to figshare by Ashim Bhattacharya, contains results from applying a Peptidisc-enabled data-independent acquisition mass spectrometry workflow to define disease- and drug-induced remodeling of the cortical membrane proteome. Female wildtype and APP/PS1 mice were aged to 9 months and treated with the M1 positive allosteric modulator VU0486846.

Use Cases

• Identify Alzheimer's disease-linked membrane proteins based on genotype-specific enrichment patterns described in the study.
• Analyze pathways related to calcium signaling and synaptic organization based on broader proteomic shifts mentioned in the description.
• Investigate the effects of M1 muscarinic receptor modulation on neuronal trafficking and synaptic plasticity proteins in a disease model.
• Compare membrane proteome profiles between wildtype and APP/PS1 mouse models as described in the experimental design.

Strengths

• Data is derived from a validated pathological context, with enrichment of APP in cortical membranes of APP/PS1 mice confirmed.
• The study uses a specific membrane-mimetic workflow (Peptidisc-enabled DIA-MS) designed to interrogate membrane-centered pathology.
• Dataset size is 6.8 MB, indicating a focused and likely manageable dataset for analysis.

Limitations

• Row count is unknown, which may limit suitability assessment for certain statistical analyses.
• Column-level documentation is absent; field semantics must be inferred after download from the XLSX file.
• Data is from a specific mouse model (female APP/PS1 mice aged to 9 months), which may limit generalizability.

Provenance

Source

figshare

Collection Method

Peptidisc-enabled data-independent acquisition mass spectrometry (DIA-MS) applied to cortical membrane samples.

Freshness

Last updated 2026-05-02 01:43:25; freshness should be verified.