MEN1 Deficiency in HCC: Mouse Model RNA-Seq and Phenotypic Data

44.3 MB of data from a study investigating the role of MEN1/menin deficiency in suppressing hepatocellular carcinoma via mitophagy disruption. The dataset, authored by Chaochun Chen and last updated in May 2026, includes results from a genetically engineered mouse model and human HCC tissue analysis. It likely contains RNA-sequencing results, phenotypic measurements, and immunohistochemistry data supporting the mechanistic findings.

Use Cases

• Train models to predict HCC progression based on mitophagy-related gene expression signatures mentioned in the description.
• Analyze correlations between MEN1 expression levels and clinical outcomes using the human HCC tissue data referenced.
• Study the impact of mitochondrial dysfunction (e.g., ROS levels, ATP production) on tumorigenesis from the phenotypic measurements.
• Validate findings on the PINK1-PRKN/Parkin pathway's role in mitophagy within an HCC context.

Strengths

• Data is associated with a detailed mechanistic study published on figshare.
• Includes results from both a genetically engineered mouse model and human HCC tissue analysis.
• Dataset size is 44.3 MB, indicating a contained but potentially detailed collection of results.

Limitations

• Row count and specific column definitions are unknown, requiring manual inspection after download.
• Description metadata is limited; actual data quality and structure require verification.
• Data may reflect the specific experimental models (e.g., DEN- and CCl4-induced mouse model) used in the study.

Provenance

Source

figshare, author Chaochun Chen

Collection Method

Likely generated from laboratory experiments including RNA-sequencing, immunofluorescence, and mouse model phenotyping.

Freshness

Last updated 2026-05-29 05:20:06