Metabolomic Changes in Permethrin-Resistant Anopheles Mosquitoes from Cameroon

Cameroon-derived Anopheles gambiae mosquitoes were analyzed using ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS). The dataset compares metabolic profiles between permethrin-resistant and susceptible mosquito samples to investigate resistance mechanisms. It was authored by Steve V. Djova and last updated on 2026-05-28.

Use Cases

• Identify metabolic biomarkers for insecticide resistance based on upregulated metabolites like inosine and dipeptides.
• Model energy production pathways in resistant mosquitoes based on features like aldopentoses and fumarate.
• Investigate neurotoxicity mechanisms in susceptible phenotypes based on metabolites like N-acetyl-aspartic acid and xanthurenic acid.
• Analyze shifts in amino acid and tryptophan catabolism linked to susceptibility based on described metabolite levels.

Strengths

• Data generated using UHPLC-HRMS/MS, a high-resolution analytical technique.
• Specific metabolic differences between resistant and susceptible phenotypes are described in detail.
• Dataset is openly available under a CC-BY-NC-4.0 license.

Limitations

• Row count and column-level documentation are unknown, limiting suitability assessment.
• The dataset is small in scale at 285.8 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) analysis of field-derived mosquito samples.

Freshness

Last updated 2026-05-28 07:16:10; freshness should be verified.

Geography

Cameroon