Metabolomic Changes Underpinning Permethrin Resistance in Anopheles gambiae from Cameroon

Ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) was used to analyze metabolic changes in field-derived Anopheles gambiae mosquitoes from Cameroon. The 302.4 KB dataset compares resistant and susceptible phenotypes, identifying metabolites like inosine, nicotinic acid, and dipeptides. Author Steve V. Djova published the data on figshare under a CC-BY-NC-4.0 license, last updated on May 28, 2026.

Use Cases

• Identify metabolic biomarkers for permethrin resistance based on upregulated levels of inosine, nicotinic acid, and dipeptides.
• Investigate energy production pathways in resistant mosquitoes based on features like aldopentoses and fumarate.
• Compare neurotoxicity and energy disruption markers in susceptible phenotypes based on metabolites like N-acetyl-aspartic acid and xanthurenic acid.
• Study cross-resistance mechanisms to pyrethroids based on altered metabolic-based detoxification pathways.

Strengths

• Data generated using UHPLC-HRMS/MS, a high-resolution analytical technique.
• Specific metabolites linked to resistance (e.g., inosine, dipeptides) and susceptibility (e.g., N-acetyl-aspartic acid, xanthurenic acid) are identified in the description.
• Dataset is openly available under a CC-BY-NC-4.0 license.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The 302.4 KB file size indicates a tiny dataset with limited scope.

Provenance

Source

figshare

Collection Method

Ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) analysis of field-derived mosquito samples.

Freshness

Last updated 2026-05-28 07:16:11; freshness should be verified.

Geography

Cameroon