Metabolomic Changes Underpinning Permethrin Resistance in Anopheles gambiae from Cameroon

A metabolomic dataset comparing resistant and susceptible Anopheles gambiae mosquitoes from Cameroon, generated using ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS). The dataset was authored by Steve V. Djova and last updated on May 28, 2026. It is a 15.7 MB CSV file shared under a CC-BY-NC-4.0 license.

Use Cases

• Identify metabolic biomarkers of permethrin resistance based on upregulated metabolites like inosine and nicotinic acid.
• Investigate metabolic pathways associated with insecticide susceptibility based on compounds like N-acetyl-aspartic acid and xanthurenic acid.
• Model the relationship between altered energy production and resistance phenotypes using features like dipeptides and aldopentoses.
• Analyze cross-resistance mechanisms to pyrethroids by studying shifts in amino acid and tryptophan catabolism pathways.

Strengths

• Data generated using a high-resolution analytical technique (UHPLC-HRMS/MS).
• Specific metabolites associated with resistance and susceptibility phenotypes are identified in the description.
• Dataset size is 15.7 MB, indicating a defined scope.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Ultra-high-performance liquid chromatography coupled with high-resolution tandem mass spectrometry (UHPLC-HRMS/MS) analysis of field-derived Anopheles gambiae mosquitoes.

Freshness

Last updated 2026-05-28 07:16:07; freshness should be verified.

Geography

Cameroon