Metabolomic Patterns of Dietary Protein and Cardiometabolic Risk from 87 Studies

Nicole Min Yee Wong's 2026 study on figshare synthesizes metabolomic responses to dietary protein intake from 87 human randomized controlled trials. The 276.3 KB DOCX file contains a systematic review and meta-analysis comparing higher versus lower protein intake and animal versus plant protein consumption. Outcomes were synthesized using MetaboAnalyst 6.0 and the amanida R package.

Use Cases

• Identify metabolomic biomarkers for dietary protein intake based on amino acid and phospholipid profiles.
• Model associations between protein source (animal vs. plant) and cardiometabolic risk factors using bile acid and microbial metabolite data.
• Validate or inform the design of clinical nutrition trials using the synthesized evidence from 87 studies.

Strengths

• Synthesizes data from 87 human randomized controlled trials, providing a substantial evidence base.
• Includes 85 comparisons for protein quantity and 17 comparisons for protein source, offering multiple analytical angles.
• Analysis performed with established tools (MetaboAnalyst 6.0, amanida R package) and quality assessed with Cochrane Risk of Bias 2.

Limitations

• Row count and column-level data are unknown, limiting suitability assessment for direct ML modeling.
• The dataset is a 276.3 KB DOCX document, which may require manual extraction of structured data for analysis.
• Description metadata is limited; actual data quality and structure require manual inspection after download.

Provenance

Source

figshare, author Nicole Min Yee Wong.

Collection Method

Systematic review and meta-analysis of human randomized controlled trials.

Time Range

Temporal coverage of the included studies is not specified.

Freshness

Last updated 2026-04 17 07:41:32.

Geography

Spatial coverage of the included studies is not specified.