Metabolomic Profiles and Bioactivities of Mangrove Actinomycetes

Twenty actinomycete strains isolated from mangrove sediments in Quanzhou, China, were profiled for antibacterial and cytotoxic activities. UPLC-QTOF-MS/MS analysis annotated 47 secondary metabolites, revealing strain-specific chemical patterns correlated with bioactivity.

Use Cases

• Correlate metabolite profiles with antibacterial activity data, such as inhibition zone diameters against Escherichia coli, to identify bioactive chemotypes.
• Analyze strain-specific secondary metabolites lacking database matches to discover novel natural product candidates.
• Compare cytotoxic IC50 values across human cancer cell lines (HeLa, A549) to rank Streptomyces malaysiensis and Streptomyces sp. strains for potency.
• Map the distribution of known bioactive polyketides among the 20 non-redundant actinomycete strains to assess chemical diversity.

Strengths

• Metabolite profiling annotated 47 distinct secondary metabolites.
• Bioactivity data includes quantitative measurements like inhibition zone diameters and IC50 values for cytotoxicity.
• Focus on 20 non-redundant actinomycete strains from a specific mangrove sediment environment.

Limitations

• Small sample size of only 20 bacterial strains limits statistical power for broad generalizations.
• Data is presented in document formats (DOCX, PDF), not a structured, machine-readable table, requiring manual extraction for computational analysis.
• Geographic scope is limited to a single collection site in Quanzhou, China.

Provenance

Source

figshare, author Bonan Yan.

Collection Method

Strains isolated from mangrove sediments, with bioactivity assays and UPLC-QTOF-MS/MS-based metabolite profiling.

Time Range

null

Freshness

Last updated March 2026.

Geography

Mangrove sediments collected in Quanzhou, China.