Brain Glucose Metabolism in Adults Under Methylphenidate and Cognitive Task

Data from a study by Nora D. Volkow of the National Institute on Drug Abuse on the effects of methylphenidate on brain glucose utilization. It includes measurements from 23 healthy adults using Positron Emission Tomography (PET) with 2-deoxy-2[18F]fluoro-D-glucose during baseline, cognitive tasks, and drug administration. The dataset likely contains quantitative metrics of brain glucose metabolism under different experimental conditions.

Use Cases

• Modeling the relationship between stimulant administration and brain glucose metabolism based on PET scan data.
• Analyzing individual differences in cognitive task performance under methylphenidate versus placebo conditions.
• Investigating the signal-to-noise ratio hypothesis in neuronal activity using metabolic efficiency metrics.

Strengths

• Data is from a controlled study with 23 human subjects.
• Includes measurements from four distinct experimental conditions per subject (baseline, task with placebo, task with drug, drug without task).
• Uses a standardized neuroimaging method (PET with FDG) for measuring brain glucose metabolism.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Nora D. Volkow, National Institute on Drug Abuse

Collection Method

Experimental data collected via Positron Emission Tomography (PET) scans on human subjects in a clinical research setting.