Candida auris Micafungin Resistance Evolution with Genomic and Virulence Data

Experimental microevolution of two Candida auris isolates generated strains with stable echinocandin resistance and increased azole tolerance. Whole-genome sequencing revealed mutations in FKS1 and other genes, while murine infection models showed retained or enhanced colonization. This 1.1 MB dataset, authored by Flora Bohner and last updated in May 2026, includes findings suggesting C. auris can acquire resistance without compromising pathogenicity.

Use Cases

• Analyzing genomic mutations linked to antifungal resistance based on whole-genome sequencing results
• Studying the relationship between drug resistance and in vivo fitness based on murine infection model data
• Comparing resistance profiles across independently evolved strains based on similar antifungal resistance profiles
• Investigating ergosterol biosynthesis pathway changes based on mutations in ERG3 and related genes

Strengths

• Includes whole-genome sequencing data revealing clinically relevant mutations in FKS1 and other genes.
• Compares in vitro drug sensitivity with in vivo colonization results from a murine systemic infection model.
• Data is derived from experimental microevolution of two distinct source isolates, allowing for reproducibility checks.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect experimental bias inherent to the in vitro evolution and murine model system.

Provenance

Source

figshare, author Flora Bohner

Collection Method

Experimental microevolution of Candida auris isolates, followed by whole-genome sequencing and murine infection modeling.

Freshness

Last updated 2026-05-21 10:00:40; freshness should be verified.