Mice-Protein-Expression

77 protein expression levels measured in the cerebral cortex of 72 mice, including 34 with Down syndrome (trisomy). The dataset contains 1080 measurements per protein across 8 classes defined by genotype (control/trisomy), learning stimulation, and drug (memantine/saline) treatment. Clara Higuera and Katheleen J. Gardiner contributed the data, which was collected to assess associative learning in a fear conditioning task.

Use Cases

• Classifying mouse genotype (control vs. trisomy) based on protein expression profiles.
• Predicting behavioral response (context-shock vs. shock-context) from proteomic data.
• Analyzing the effect of memantine treatment on protein expression in trisomic mice.
• Identifying protein biomarkers associated with associative learning deficits.

Strengths

• Includes 1080 measurements per protein across 72 mice, providing multiple observations.
• Structured design with 8 clearly defined experimental classes combining genotype, behavior, and treatment.
• Protein measurements are from the nuclear fraction of cortex, a specific biological compartment.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

Clara Higuera (University Complutense, Madrid) and Katheleen J. Gardiner (University of Colorado School of Medicine).

Collection Method

Experimental measurement of protein expression levels in mouse cerebral cortex samples.