Microglia in Nanozyme Hydrogels: Response to Oxidative Stress and Inflammation

Sara Martín-Colomo created this dataset on 2026-05-08 to investigate the role of hydrogel composition and nanozyme incorporation on the inflammatory response of encapsulated murine microglia. The 264.9 MB collection of TIF/TIFF files likely contains microscopy images from experiments assessing cell-biomaterial interactions and cytokine expression under normal and LPS-stimulated conditions. Findings include a 7-fold increase in IL-6 expression with high-molecular-weight hyaluronic acid and a 2.4-fold increase in Arg-1 expression with Mn3O4 nanoparticles under prolonged LPS exposure.

Use Cases

• Analyze cell morphology and aggregation based on hydrogel composition mentioned in the description
• Study cytokine expression levels (e.g., IL-6, TNF-α, IL-1β, IL-4, Arg-1) under different stimulation conditions described
• Evaluate the protective effect of Mn3O4 nanoparticle-loaded hydrogels against hydrogen peroxide-induced oxidative stress
• Compare the pro- and anti-inflammatory effects of hyaluronic acid with different molecular weights on encapsulated microglia

Strengths

• Dataset includes specific quantitative results, such as a 7-fold increase in IL-6 expression and a 2.2-fold increase in TNF-α secretion.
• The 264.9 MB size suggests a medium-scale collection of detailed image data.
• Clear experimental conditions are described, including hydrogel compositions and LPS stimulation protocols.
• Released under a permissive CC-BY-4.0 license for reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The description is detailed but does not specify the exact number or naming convention of the image files.

Provenance

Source

figshare

Collection Method

Experimental data from preparing and characterizing sodium alginate hydrogels with hyaluronic acid and Mn3O4 nanoparticles, followed by assessment of encapsulated murine microglia inflammatory response.

Freshness

Last updated 2026-05-08 09:07:11; freshness should be verified.