Microneedle-Based Amphotericin B Treatment Efficacy for Cutaneous Leishmaniasis in Mice

A research study evaluates hollow microneedle delivery of Amphotericin B for treating American cutaneous leishmaniasis in mice. The dataset likely contains experimental results on lesion growth, parasitic burden, and toxicity markers from 20- and 10-day treatment trials. Ryan H. Huston authored the study, which was last updated on 2026-05-05.

Use Cases

• Analyze treatment efficacy based on lesion growth reduction data mentioned in the description
• Compare systemic toxicity based on blood serum creatinine and urea nitrogen levels
• Evaluate immunological response based on flow cytometry explorations of IL-17 and IFN-γ positivity
• Assess parasitic burden reduction weeks after treatment cessation using limiting dilution data

Strengths

• Results include specific lesion growth reduction measurements (up to 2.8 mm difference)
• Statistical significance data is provided (p-values for 10-day and 20-day trials)
• Toxicity assessment includes concrete biochemical markers (creatinine, blood urea nitrogen)

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is 1.9 MB, suggesting a small scale of data

Provenance

Source

figshare

Collection Method

Experimental study using Leishmania mexicana-infected mice

Freshness

Last updated 2026-05-05 06:00:03; freshness should be verified