Micronutrient Associations with COVID-19 Outcomes from 57 Reviews and Studies

57 reviews and 57 original studies were included in an umbrella review exploring micronutrient links to COVID-19. The analysis, registered as PROSPERO CRD42022353953, found vitamin D, zinc, and calcium deficiencies increased mortality by 0.53-fold, 0.46-fold, and 5.99-fold, respectively. Literature searches were conducted on PubMed, Web of Science, Embase, Cochrane Library, and Scopus in July and October 2022.

Use Cases

• Modeling the association between vitamin D deficiency and COVID-19 infection risk based on reported 0.97-fold increase
• Analyzing the impact of zinc levels on disease severity based on the described 1.53-fold increase in infection
• Investigating the relationship between calcium deficiency and ICU admission based on the reported 4.09-fold increase
• Comparing the effects of different micronutrients on mortality based on the reported fold-changes for vitamin D, zinc, and calcium

Strengths

• Includes 57 reviews and 57 original studies, with 21 reviews and 53 original studies rated moderate to high quality
• Analysis provides specific fold-change estimates for multiple micronutrients (e.g., vitamin D, zinc, calcium) across different COVID-19 outcomes
• Literature selection and data extraction were performed in a double-blinded, group discussion format

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• Last update date is unknown; freshness unverified

Provenance

Source

paperswithcode

Collection Method

Umbrella review and reanalysis of meta-analyses from PubMed, Web of Science, Embase, Cochrane Library, and Scopus

Time Range

Literature search conducted on July 30, 2022 and October 15, 2022