miR-29c-3p/FOXP1/ATG14 Pathway Data for Ovarian Cancer Drug Resistance

Experimental data from a study investigating the miR-29c-3p/FOXP1/ATG14 pathway's role in autophagy and cisplatin resistance in ovarian cancer. The dataset likely contains measurements from DDP-sensitive and DDP-resistant ovarian cancer cell lines (SKOV3, A2780) and in vivo xenograft models. The research was conducted by Zhenhua Hu of the Chinese Academy of Sciences.

Use Cases

• Modeling the relationship between miR-29c-3p expression and cisplatin resistance based on cell viability assays.
• Analyzing the regulatory interaction between FOXP1 and ATG14 based on luciferase and ChIP assay results.
• Investigating autophagy markers in drug-resistant versus sensitive ovarian cancer cell lines.

Strengths

• Data is derived from controlled experiments using established cell lines (SKOV3, A2780) and their DDP-resistant counterparts.
• Findings are validated through multiple assay types including MTT, luciferase reporter, and ChIP assays.
• Includes in vivo validation from a xenograft mouse model.

Limitations

• Row count and specific column definitions are unknown, limiting suitability assessment.
• Last update date is unknown; freshness unverified.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

paperswithcode, authored by Zhenhua Hu, Chinese Academy of Sciences.

Collection Method

Experimental laboratory data from cell culture and animal models.