miR-4725-3p Role in Lung Adenocarcinoma Low-Dose Radiosensitivity

Research data from a study investigating low-dose hyper-radiosensitivity in lung adenocarcinoma cells. The dataset likely contains results from high-throughput miRNA sequencing and bioinformatics analysis related to the NRAS/PI3K/AKT/p53 signaling pathway. It was authored by Jiang Xiao and last updated on May 24, 2026.

Use Cases

• Validate miR-4725-3p as a regulator of the PI3K/AKT/p53 pathway based on high-throughput sequencing results.
• Investigate the role of NRAS as a direct target of miR-4725-3p in lung adenocarcinoma cell lines.
• Model cellular sensitivity to low-dose irradiation based on p53 and PI3K/AKT pathway activity.
• Compare miRNA expression profiles between wild-type p53 overexpressing and control cell lines.

Strengths

• Dataset size is 104.2 MB, indicating a medium-scale collection of results.
• License is CC-BY-4.0, permitting broad reuse for research and commercial purposes.
• Data originates from a specific experimental study constructing stable cell lines and using pathway inhibitors.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from high-throughput miRNA sequencing, bioinformatics analysis, and in vitro cell line studies.

Freshness

Last updated 2026-05-24 11:30:07; freshness should be verified.