miR-4772-3p Expression and Clinical Outcomes in Septic Acute Kidney Injury

192 septic patient records (99 without AKI, 93 with AKI) were analyzed by Qiang Chen to investigate a potential biomarker. miR-4772-3p expression levels were measured and correlated with clinical indicators like serum creatinine, SOFA score, and mortality. The dataset, last updated in May 2026, includes results from in vitro cell model experiments targeting the CISD2 gene.

Use Cases

• Train a diagnostic classifier for septic AKI based on miR-4772-3p expression levels.
• Build a prognostic model for patient mortality using miR-4772-3p and clinical scores (SOFA, APACHE II).
• Investigate molecular pathways linking miR-4772-3p to kidney cell injury via its target CISD2.
• Validate biomarker candidates for sepsis complications using clinical and laboratory correlation data.

Strengths

• Includes data from 192 patients, a specific cohort size for biomarker studies.
• Links molecular data (miRNA expression) to multiple clinical parameters like cystatin C, creatinine, and organ failure scores.
• Provides experimental validation from an LPS-induced cell model assessing viability, apoptosis, and inflammation.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 42.4 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Clinical study and laboratory experiments (RT-qPCR, ELISA, flow cytometry, dual-luciferase assay).

Freshness

Last updated 2026-05-17 23:06:49; freshness should be verified.