miR-769-5p and Follistatin Expression in Endometriosis: In Vitro Study Data

A study by Yibo Meng, last updated in April 2026, investigates microRNA-769-5p in endometriosis. Data includes serum samples from 120 patients and 100 healthy controls, with results from RT-qPCR, cell proliferation, migration, and invasion assays. The findings indicate miR-769-5p targets follistatin to inhibit cellular behaviors associated with disease progression.

Use Cases

• Validate miR-769-5p as a diagnostic biomarker for endometriosis based on its reported AUC of 0.9166.
• Study the inhibitory effects of miR-769-5p on cell proliferation, migration, and invasion in endometriosis models.
• Analyze the regulatory relationship between miR-769-5p and its target gene follistatin (FST).
• Benchmark in vitro assay results (CCK-8, Transwell, dual-luciferase) from the hEM15A stromal cell line.

Strengths

• Includes data from a defined cohort of 120 endometriosis patients and 100 healthy controls.
• Reports a high diagnostic accuracy for miR-769-5p with an AUC of 0.9166 (p < 0.001).
• Functional assay results (proliferation, migration, invasion) are supported by statistical significance (p < 0.001).

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is derived from an in vitro cell line model (hEM15A), which may not fully represent in vivo complexity.

Provenance

Source

figshare

Collection Method

Experimental study using RT-qPCR, CCK-8, Transwell, and dual-luciferase assays on serum samples and a cell line.

Time Range

The study period is not specified.

Freshness

Last updated 2026-04-30 16:20:44; freshness should be verified.

Geography

The geographic origin of the patient samples is not specified.