MicroRNA Profiles in Mutation-Negative and PKD1/PKD2 ADPKD Patients

Bruna De Felice's study profiles microRNA expression in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD). The dataset compares mutation-negative patients with those carrying PKD1 or PKD2 mutations and healthy controls. The research was published in April 2026.

Use Cases

• Identify differentially expressed miRNAs like miR-92a-3p and miR-134-5p across patient groups using statistical contrasts.
• Build classifiers to distinguish mutation-negative ADPKD from PKD1 or PKD2 groups based on miRNA expression signatures.
• Analyze miRNA-mRNA interaction networks related to extracellular-matrix remodeling and cyst formation pathways.
• Validate miR-92a-3p as a potential blood-based biomarker for ADPKD across all genetic subgroups.

Strengths

• Includes data from four distinct cohorts: PKD1, PKD2, mutation-negative ADPKD, and healthy controls.
• Analysis uses five prespecified statistical contrasts with Welch's t-test (p < 0.05).
• Results are interpreted using experimentally supported miRNA-mRNA interaction networks.

Limitations

• Dataset is small at 53.5 KB, indicating limited sample size and scope.
• Specific row counts, column names, and raw expression values are not provided.
• Geographic origin and detailed demographic information for the cohort are unknown.

Provenance

Source

Bruna De Felice via figshare.

Collection Method

Targeted microRNA profiling from patient blood samples.

Freshness

Last updated April 2026.