CVP-764: Fis1/Mid51 Inhibitor Binding and Cell Viability Data

662 bytes of data from a study developing macrocyclic inhibitors targeting the Fis1/Mid51 protein-protein interaction implicated in cardiovascular disease. The dataset, authored by Mulate Zerihun and last updated in May 2026, likely contains results from fluorescence polarization binding assays and cell viability tests in H9c2 cardiomyocytes. It describes compounds CVP-240 and CVP-764, which exhibit nanomolar binding affinity and improve cell viability under stress.

Use Cases

• Analyze binding affinity relationships based on fluorescence polarization assay data mentioned in the description
• Model structure-activity relationships for macrocyclic peptide inhibitors based on the described optimization from CVP-240 to CVP-764
• Evaluate cell permeability and proteolytic stability enhancements based on the described macrocyclization effects
• Assess preliminary safety profiles for drug candidates based on the mentioned in silico ADMET and in vivo toxicity studies

Strengths

• Data is associated with a specific, peer-reviewed research project developing selective inhibitors CVP-240 and CVP-764
• Description provides concrete performance metrics, including nanomolar binding affinity and improved cell viability in H9c2 cardiomyocytes

Limitations

• Dataset size is only 662 bytes, indicating extremely limited scope and likely a minimal subset of the full study data
• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

figshare

Collection Method

Likely contains experimental results from homologous sequence analysis, structure-guided design, fluorescence polarization assays, and cell culture studies.

Freshness

Last updated 2026-05-23 13:32:54; freshness should be verified