MMP9 as a shared immune-related gene in Alzheimer’s and Huntington’s diseases: a cross-tis

2,160 immune-related genes were analyzed across peripheral blood and frontal cortex tissues to identify shared immunopathology in Alzheimer's and Huntington's diseases. The dataset, authored by Xuepan Li and last updated in April 2026, includes results from differential analysis and machine learning models. MMP9 was identified as a core shared immune hub gene, with its diagnostic performance validated in external datasets.

Use Cases

• Identifying shared immune-related biomarkers based on cross-tissue transcriptomic profiles
• Validating machine learning-derived gene targets like MMP9 based on external validation results
• Analyzing correlations between gene expression and immune cell infiltration based on neutrophil and M0 macrophage data
• Studying functional enrichment pathways such as IL-17 and T-cell receptor signalling based on the analysis

Strengths

• Analysis integrates transcriptomic profiles from two distinct tissue types (peripheral blood and frontal cortex)
• Focuses on a curated set of 2,160 immune-related genes
• Results include external validation of diagnostic performance metrics (AUC values)
• Machine learning methods (LASSO and Boruta) were applied to identify core genes

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment
• The dataset is 6.0 MB, suggesting a relatively small scale for transcriptomic data

Provenance

Source

figshare

Collection Method

Integrative analysis of transcriptomic profiles from peripheral blood and brain tissues.

Freshness

Last updated 2026-04-24 23:00:03; freshness should be verified