Mouse Study Data on Chlorpyrifos Mobilization During Weight Loss

88.6 KB of tabular data from a controlled mouse study investigating the release of the pesticide chlorpyrifos from fat during weight loss. The dataset, authored by Yifan Xiang and last updated in April 2026, includes measurements of toxicant levels in serum, liver, adipose, and brain tissue, alongside gene expression and metabolic markers. Results indicate weight loss can mobilize stored toxicants, leading to tissue accumulation and metabolic disruption even at low, human-relevant doses.

Use Cases

• Modeling the relationship between weight loss and toxicant mobilization based on quantified chlorpyrifos levels in serum and tissues.
• Analyzing gene expression patterns related to toxicant metabolism, such as Paraoxinase-1 and cytochrome P450 genes.
• Investigating metabolic disruption by correlating glucose intolerance data with molecular markers like AMPK signaling and P62 accumulation.
• Comparing tissue-specific toxicant accumulation and damage, such as liver fibrosis and adipose inflammation, across different diet and exposure groups.

Strengths

• Data includes measurements at human-relevant low doses (0.45 mg/kg BW/day).
• Findings are reported to be consistent across sexes.
• Study design includes multiple weight loss interventions (β3-adrenergic stimulation and treadmill exercise) over 4 or 10 weeks.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (88.6 KB), indicating limited scope.

Provenance

Source

figshare, author Yifan Xiang.

Collection Method

Data generated from a controlled laboratory study on C57BL/6J mice exposed to chlorpyrifos via oral gavage, with analyses including HPLC quantification, tissue histology, and molecular assays.

Time Range

Study duration involved interventions lasting 4 or 10 weeks.

Freshness

Last updated 2026-04-16 19:35:20; freshness should be verified.

Geography

Laboratory study; geographic coverage is not specified.