Cellular Responses to Serum and Vitamin D in Microgravity Using a Kidney Model

A dataset from NASA experiments aboard the International Space Station (ISS) to evaluate the effects of microgravity on human kidney proximal tubule epithelial cells. The study measured biomarkers KIM-1 and IL-6, conducted global transcriptomics via RNAseq, and monitored vitamin D metabolite formation. Data was last updated in March 2026.

Use Cases

• Modeling kidney cell inflammatory response based on measured biomarkers KIM-1 and IL-6
• Analyzing transcriptomic changes in kidney cells under microgravity stress based on RNAseq data
• Studying vitamin D biotransformation pathways in kidney cells based on metabolite formation measurements
• Comparing fundamental biochemical pathway resilience based on the described microgravity versus ground control experiments

Strengths

• Data originates from a controlled experiment aboard the International Space Station, a unique environment.
• Includes multiple data modalities: biomarker measurements and global transcriptomics via RNAseq.
• Produced by the authoritative organization National Aeronautics and Space Administration (NASA).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and dataset scale are unknown, which may limit suitability assessment.
• The description indicates the study focused on short-term exposure; applicability to long-term spaceflight is noted as requiring more study.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Experimental data from kidney proximal tubule epithelial cells cultured in a microphysiological system aboard the ISS and corresponding ground controls.

Time Range

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Freshness

Last updated 2026-03-13 20:05:55.916833; freshness should be verified.

Geography

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