Cannabis sativa Extract Effects on HepG2 Cells Under High Glucose Conditions

Cannabis sativa aqueous extract significantly elevated ATP levels in HepG2 cells under hyperglycemic conditions. The dataset likely contains results from in vitro assays measuring cell viability, metabolic activity, oxidative damage, and phytochemical composition of three different extracts. It was authored by Anevay Africa and last updated on figshare in April 2026.

Use Cases

• Model the relationship between cannabis extract dosage and total antioxidant content based on the described assays.
• Compare the hepatoprotective effects of acetone, ethanolic, and aqueous extracts based on the described in vitro glucotoxic model.
• Analyze the phytochemical fingerprint for compounds like CBD and THC based on the LC/MS method mentioned.
• Investigate the correlation between oxidative damage markers (e.g., TBARS) and cell viability under hyperglycemic conditions.

Strengths

• Phytochemical composition was determined using liquid chromatography/mass spectrometry (LC/MS).
• Antioxidant capacity was evaluated using three distinct cell-free assay methods: TPC, DPPH, and FRAP.
• Biological effects were assessed across multiple endpoints: cell viability, metabolic activity, oxidative damage, and cellular death.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is focused on a specific in vitro cell line model (HepG2), limiting generalizability.

Provenance

Source

Anevay Africa via figshare

Collection Method

In vitro laboratory experiments on HepG2 cells, with phytochemical analysis via LC/MS.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04-15 08:03:00; freshness should be verified.

Geography

Geographic origin of the study or data is not specified.