Molecular Interactions of Indoor Smoke Components with the Tear Film Lipid Layer

An atomistic model quantifies interactions between six priority indoor smoke constituents and the tear film lipid layer under indoor-relevant conditions. The dataset, created by Changcheng Gao and last updated in April 2026, includes findings on permeability, agglomerate formation, and film rupture mechanics. It provides quantitative thresholds for classifying ocular hazards from smoke components.

Use Cases

• Predicting trans-tear film permeability of airborne chemicals based on their hydrophobicity (log P).
• Modeling the impact of polar cooking and biomass smoke markers on tear film stability and water evaporation.
• Classifying indoor smoke components as ocular hazards based on quantitative thresholds for film rupture and antievaporation loss.

Strengths

• Includes six priority indoor smoke constituents covering the full hydrophobicity spectrum.
• Quantifies permeability differences spanning 3–4 orders of magnitude between polar and hydrophobic molecules.
• Proposes a three-variable phase diagram for predicting component behavior, translating chemical concentration into trans-film flux.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect modeling assumptions and parameter bias inherent to the computational approach.

Provenance

Source

Changcheng Gao via figshare

Collection Method

Computational construction of an atomistic tear film lipid layer model and simulation of interactions.

Freshness

Last updated 2026-04-20 21:45:02; freshness should be verified.