Lake Trout Transcriptomic Response to 6PPD-Quinone Toxin

Junyi Lin's 2026 dataset on figshare contains transcriptomic data from lake trout alevins exposed to the environmental contaminant 6PPD-quinone. The XLSX file, 14.5 MB in size, includes results from a whole-transcriptome analysis of fish exposed to concentrations ranging from 0.22 to 7.6 μg/L for 96 hours. It provides concentration-dependent gene expression data used to model transcriptomic points of departure.

Use Cases

• Model transcriptomic benchmark concentrations (BMC10th) from gene expression profiles to predict apical toxicity thresholds.
• Analyze dysregulation of specific pathways like inflammation, oxidative stress, and skeletal development across graded exposure concentrations (0.22–7.6 μg/L).
• Identify early activation markers of programmed cell death processes, such as efferocytosis and ferroptosis, in exposed alevins.
• Correlate short-term transcriptomic responses in embryonic life stages with longer-term 45-day apical toxicity data.

Strengths

• Data is derived from a whole-transcriptome analysis, providing a broad view of molecular responses.
• Includes benchmark concentration modeling results (e.g., transcriptomic BMC10th of 0.211 μg/L) aligned with apical endpoints.
• Exposure concentrations are precisely defined across a relevant environmental range (0.22–7.6 μg/L).

Limitations

• Dataset is relatively small at 14.5 MB, limiting the depth of raw sequence data included.
• Focus is on a single species (lake trout) and life stage (alevins), restricting generalizability to other fishes.
• Temporal coverage is limited to a 96-hour exposure window, though linked to a 45-day study.

Provenance

Source

figshare, authored by Junyi Lin.

Collection Method

Whole-transcriptome analysis of lake trout alevins exposed to graded concentrations of 6PPD-quinone in a laboratory study.

Time Range

Experimental exposure duration was 96 hours; dataset publication date is 2026.

Freshness

Last updated on 2026-04-08.

Geography

Study likely conducted in a North American laboratory context, given the species' significance in North America.