Lake Trout Transcriptomic Responses to 6PPD-Quinone Exposure

Transcriptomic data from a 2026 study by Junyi Lin on early-life stage lake trout alevins exposed to 6PPD-quinone concentrations from 0.22 to 7.6 μg/L for 96 hours. The dataset includes whole-transcriptome analysis results, identifying concentration-dependent dysregulation of pathways related to inflammation, vascular integrity, and development. It provides benchmark concentration (BMC) modeling values for transcriptomic responses.

Use Cases

• Model transcriptomic benchmark concentrations (BMC10th) from gene expression data to predict apical toxicity thresholds.
• Analyze concentration-dependent dysregulation of specific pathways like inflammation, oxidative stress, and skeletal development from transcriptomic profiles.
• Compare transcriptomic responses in lake trout alevins to known sensitivity data for other salmonid species.
• Identify early activation markers for programmed cell death processes such as necroptosis and ferroptosis from exposure data.

Strengths

• Includes quantitative benchmark concentration (BMC) modeling results, with a transcriptomic BMC10th of 0.211 μg/L.
• Covers a defined exposure concentration range (0.22–7.6 μg/L) over a 96-hour period for mechanistic insight.
• Data is associated with a peer-reviewed study focused on a species of significant ecological and economic importance.

Limitations

• Dataset is very small at 174.7 KB, indicating limited raw data or summary-level results only.
• Scope is restricted to a single species (lake trout) and a single life stage (alevins), limiting generalizability.
• Specific row count, column names, and individual gene expression values are not provided in the metadata.

Provenance

Source

Figshare, authored by Junyi Lin.

Collection Method

Whole-transcriptome analysis of lake trout alevins exposed to graded concentrations of 6PPD-quinone in a laboratory study.

Time Range

Experimental exposure period was 96 hours; dataset publication date is 2026.

Freshness

Last updated in April 2026, indicating recent data.

Geography

Study organism (lake trout) is native to North America; specific laboratory location is unknown.