bOPV Vaccine Potency and VVM Degradation Across Storage Temperatures

50 vials of bivalent Oral Polio Vaccine (bOPV) were tested weekly to monitor infectious titer and Vaccine Vial Monitor color degradation under different storage conditions. The study found potency was preserved under refrigeration for 6 months, at room temperature for 2 weeks, and at incubator temperatures for a week, but degraded severely at atmospheric temperatures within a week. This dataset was authored by Mercy Doose Yough and last updated on 2026-05-11.

Use Cases

• Predicting vaccine shelf-life based on storage temperature and VVM color progression.
• Analyzing the relationship between viral titer decay and VVM degradation stages.
• Modeling cold chain failure risks for polio vaccine distribution in low-resource settings.

Strengths

• Explicit potency and VVM degradation results are provided for four distinct temperature ranges (2–4°C, 27–29°C, 35–36°C, 22–44°C).
• The study includes a baseline of 50 vials tested before exposure, all with titers above 10^7.0 CCID50/mL.
• Results are quantified with specific percentages of samples sustaining potency and VVM degradation levels over time.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is small (653.4 KB), indicating limited scope.

Provenance

Source

figshare

Collection Method

Weekly laboratory testing of vaccine vials stored at controlled temperatures.

Freshness

Last updated 2026-05-11 18:32:32; freshness should be verified.