Monocyte Exhaustion Associated with Systemic Lupus Erythematosus

A 2.5 MB dataset from figshare, last updated on 2026-05-20, authored by Blake A. Caldwell. It contains data on monocyte immune exhaustion in systemic lupus erythematosus (SLE) pathogenesis, analyzed in lupus-prone MRL and MRL/lpr mice and recapitulated in patient samples. The dataset is available in DOCX and XLSX formats under a CC-BY-4.0 license.

Use Cases

• Correlating monocyte exhaustion severity with SLE disease progression based on the described analysis.
• Investigating altered expression of T cell regulatory molecules (PD-L1, CD200R, ICOS-L, CD86) in exhausted monocytes.
• Comparing immune exhaustion phenotypes between mouse models (MRL, MRL/lpr) and human SLE patient monocytes.
• Analyzing the relationship between reduced CX3CR1 cell surface levels and heightened endotoxin sensitivity in monocytes.

Strengths

• Dataset is 2.5 MB, indicating a focused and manageable size for analysis.
• Includes data from both a mouse model (MRL/lpr) and human SLE patients, supporting translational research.
• Explicitly licensed under CC-BY-4.0, allowing for broad reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment for large-scale analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Analysis of bone marrow and splenic reservoir monocytes from lupus-prone mice and patients with SLE.

Freshness

Last updated 2026-05-20 10:12:31; freshness should be verified.