MOUD-PK-Sim: Pharmacokinetic Simulator for Opioid Use Disorder Medications

MOUD-PK-Sim models plasma concentrations of Methadone and Buprenorphine across complex induction protocols for Medication for Opioid Use Disorder. The simulator, authored by Dayan-Rosenman, David and hosted on Harvard Dataverse, allows clinicians and researchers to visualise and compare drug exposure over time. The dataset was last updated on 2026-04-27.

Use Cases

• Visualizing drug plasma concentration over time based on the pharmacokinetic models described.
• Comparing exposure profiles between Methadone and Buprenorphine induction protocols as mentioned in the description.
• Simulating and evaluating complex clinical induction schedules for opioid use disorder treatment.
• Supporting protocol design and education for clinicians based on the modeled pharmacokinetic data.

Strengths

• Models two specific medications, Methadone and Buprenorphine, for a defined clinical purpose.
• Focuses on complex induction protocols, a specific and detailed application area.
• Last update timestamp is precisely recorded as 2026-04-27 15:39:27.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and dataset scale are unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality and completeness require manual inspection.

Provenance

Source

Harvard Dataverse

Collection Method

Pharmacokinetic simulation modeling.

Time Range

The simulation's temporal coverage is not specified.

Freshness

Last updated 2026-04-27 15:39:27; freshness should be verified.

Geography

The simulation's geographic coverage is not specified.