Mouse Hematopoiesis LARRY Data for Monocyte and Neutrophil Lineage

Figshare hosts a 1.1 GB AnnData file containing LARRY lineage tracing data for mouse monocyte and neutrophil differentiation. The dataset, created by Abdullah Al Noman for the FateSens work, is derived from single-cell RNA sequencing experiments originally published in Science. It focuses on a specific cellular trajectory from the broader hematopoietic study.

Use Cases

• Analyze single-cell transcriptional states along the monocyte-neutrophil trajectory to study fate decisions.
• Apply lineage tracing methods to understand progenitor cell differentiation using the LARRY barcoding system.
• Benchmark computational tools for single-cell analysis on a defined hematopoietic lineage dataset.

Strengths

• Dataset size of 1.1 GB indicates substantial single-cell sequencing data.
• Derived from a peer-reviewed LARRY lineage tracing study published in Science.
• Shared in the AnnData format, which is standard for single-cell analysis in Python.

Limitations

• Unknown row and column counts prevent immediate assessment of data scale and feature dimensionality.
• Data is limited to the monocyte-neutrophil trajectory, not the full hematopoietic spectrum from the original study.
• Requires specialized bioinformatics tools (e.g., Scanpy) to work with the H5AD file format.

Provenance

Source

Derived from data published in https://doi.org/10.1126/science.aaw3381 and processed by Abdullah Al Noman.

Collection Method

Single-cell RNA sequencing with LARRY lineage tracing, processed into an AnnData object.

Freshness

Last updated on 2026-03-24.