MAIT Cell Profiles in Immunotherapy-Associated Colitis

A clinical study from the University of Oxford investigates immune cell profiles in patients with combination ipilimumab and nivolumab therapy-related colitis. The dataset likely contains flow cytometry measurements of gut-derived and peripheral blood mononuclear cells from patients with colitis, ulcerative colitis, and healthy volunteers. It was authored by Sarah C. Sasson.

Use Cases

• Compare T cell activation patterns based on flow cytometry data from gut-derived cells.
• Identify biomarkers for colitis risk based on circulating MAIT cell counts mentioned in the description.
• Distinguish immunotherapy-associated colitis from ulcerative colitis based on regulatory T cell proportions.
• Analyze peripheral blood immune changes as a systemic indicator of checkpoint inhibitor treatment.

Strengths

• Data compares multiple patient cohorts: IN-COL, IN-NAE, ulcerative colitis, and healthy volunteers.
• Analysis includes both gut-derived and peripheral blood mononuclear cell profiles.
• Study design investigates a distinct pathology from ulcerative colitis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

University of Oxford

Collection Method

Flow cytometry analysis of patient samples.