Multi-target Approaches to Prion Disease Drug Discovery: A Status Update

A 16.7 KB Excel file containing a review of emerging therapeutic approaches for prion diseases. The dataset, authored by Lea Nikolić and last updated on 2026-05-06, examines strategies targeting key nodes of prion biology and discusses the potential of polypharmacology.

Use Cases

• Reviewing prion protein-targeting strategies based on the described therapeutic approaches
• Analyzing the challenges of polypharmacology based on the discussion of drug combinations and multi-target-directed ligands
• Evaluating the alignment of therapeutic strategies with disease stage and biological heterogeneity as discussed in the review

Strengths

• File size is precisely 16.7 KB, indicating a concise and focused dataset
• License is clearly defined as CC-BY-4.0, permitting open reuse with attribution
• Last update timestamp is provided (2026-05-06 05:23:51), indicating recent maintenance

Limitations

• Row count is unknown, which may limit suitability assessment
• Column-level documentation is absent; field semantics must be inferred after download
• Description metadata is limited; actual data quality requires manual inspection after download

Provenance

Source

figshare

Collection Method

Likely a manually compiled review or summary document.

Time Range

The review's publication or compilation date is implied by the 2026 last update.

Freshness

Last updated 2026-05-06 05:23:51

Geography

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