Multicationic ruthenium phthalocyanines as photosensitizers for photodynamic inactivation

Raw data from a study evaluating four multicationic ruthenium(II) phthalocyanine photosensitizers for photodynamic inactivation of multiresistant microorganisms. The dataset contains structural and photophysical characterization of the compounds, authored by Ana Belén Domínguez and last updated on 2025-10-14. The research compares the compounds' activity against Gram-positive MRSA, Gram-negative E. coli, and fluconazole-resistant C. albicans.

Use Cases

• Comparing the photodynamic inactivation efficacy of different ruthenium phthalocyanine structures based on their ammonium salt count and amphiphilic character.
• Analyzing the synergistic effect of photosensitizer PS4a with doxycycline against MRSA based on the described log reduction data.
• Modeling structure-activity relationships for photosensitizers targeting Gram-positive vs. Gram-negative bacteria based on the described performance differences.
• Investigating the impact of singlet oxygen quantum yield and multi-target localization on antimicrobial activity as described in the study.

Strengths

• Data includes specific performance metrics, such as a log reduction increase from about 1.5 to about 4.9 for a synergistic combination.
• Compares four distinct photosensitizer designs with varying cationic charges (4 to 12 ammonium salts) and amphiphilic properties.
• Evaluation covers multiple clinically relevant pathogens: MRSA, E. coli, and fluconazole-resistant C. albicans.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Ana Belén Domínguez via e-cienciaDatos Harvested Dataverse

Collection Method

Likely contains experimental measurements from photophysical characterization and microbiological assays.

Time Range

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Freshness

Last updated 2025-10-14 21:40:13; freshness should be verified.

Geography

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