Oncogene Inhibition and Phototoxicity Data for an RNA G-Quadruplex Ligand

TO-ISe, a selenium-containing photosensitizer, binds RNA G-quadruplexes with a dissociation constant of 860 nM. The dataset contains phototoxicity measurements, showing IC50 values of 0.16–0.27 μM in cancer cells versus 5.9–7.8 μM in nonmalignant cells, and reports up to 72.8% tumor growth inhibition in a mouse model. Wei Long published this experimental data on figshare in April 2026.

Use Cases

• Model the relationship between rG4 binding affinity (Kd = 860 nM) and photodynamic activity for ligand design.
• Predict cancer cell phototoxicity (IC50 = 0.16–0.27 μM) from molecular features of RNA G-quadruplex ligands.
• Analyze the correlation between oncogene suppression (c-MYC, NRAS, hTERT) and induction of ferroptosis or apoptosis.
• Evaluate tumor growth inhibition efficacy (72.8%) based on treatment dosage (0.5 mg kg–1) and irradiation parameters (22.1 mW·cm–2).

Strengths

• Reports precise quantitative binding and efficacy metrics, including a Kd of 860 nM and specific IC50 ranges.
• Includes comparative data across cell types (cancer vs. nonmalignant) and treatment conditions (dark vs. light).
• Contains in vivo validation results from an orthotopic 4T1 tumor model.

Limitations

• Dataset is extremely small at 1.4 KB, indicating limited scope and likely a summary of key results rather than raw experimental data.
• No column names or sample data are provided, making direct analysis or replication impossible without the original study.
• Temporal and geographic coverage of the underlying biological experiments is not specified.

Provenance

Source

figshare, authored by Wei Long.

Collection Method

Experimental data from chemical synthesis, in vitro assays, and in vivo mouse studies.

Freshness

Last updated April 2026.