Zebrafish Multiomics Data on Bioactive Peptide BP1 for Cardiotoxicity Protection

A 957.5 KB dataset from figshare contains transcriptomic and metabolomic results from a zebrafish study of a novel bioactive peptide. Author Shweta Thakur investigated the cardioprotective effect of peptide BP1 against isoproterenol- and doxorubicin-induced cardiac damage. The dataset, last updated in April 2026, includes results from cardiac morphology, functional parameters, transcriptome, and untargeted metabolome analyses.

Use Cases

• Identify differentially expressed genes associated with cardiotoxicity based on transcriptomic data mentioned in the description
• Analyze metabolic pathway alterations (e.g., sphingolipid, glutathione metabolism) based on untargeted metabolomics results
• Model gene co-expression networks for cardiac muscle contraction pathways using weighted gene coexpression network analysis (WGCNA) results
• Correlate cardiac functional parameters with molecular changes from the multiomics analysis

Strengths

• Data integrates multiple omics layers (transcriptome and metabolome) for a systems-level analysis.
• Experiments were conducted on two distinct zebrafish models (larvae and adult) for induced cardiac damage.
• Specific metabolic pathways, such as sphingolipid and glutathione metabolism, are identified as involved in the protective effect.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The 957.5 KB file size suggests a limited scope of data, likely focused on summary or processed results rather than raw sequencing data.

Provenance

Source

figshare

Collection Method

Experimental data from zebrafish larvae and adult models treated with isoproterenol (ISO) and doxorubicin (DOX), followed by transcriptomic and metabolomic analysis.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04-14 17:43:32; freshness should be verified.

Geography

Spatial coverage is not specified.