Multiomics Analysis of Bioactive Peptide BP1 in Zebrafish Cardiomyopathy Models

A 53.3 KB Excel dataset from figshare, last updated April 2026, containing multiomics data from a study by Shweta Thakur. The data investigates the cardioprotective effects of a novel bioactive peptide (BP1) in zebrafish models of isoproterenol- and doxorubicin-induced cardiac damage. It includes results from transcriptomic and metabolomic analyses.

Use Cases

• Identify gene expression changes associated with cardiotoxicity and treatment based on transcriptomic data.
• Analyze metabolic pathway alterations (e.g., sphingolipid, glutathione metabolism) from untargeted metabolomics results.
• Model the cardioprotective effects of bioactive peptides using combined transcriptomic and metabolomic features.
• Validate hypotheses on angiotensin-converting enzyme (ACE) inhibitory activity through multiomics integration.

Strengths

• Data is structured in an XLSX file, likely facilitating direct analysis.
• The study design includes both larval and adult zebrafish models for cardiotoxicity.
• Multiomics approach combines transcriptomic and metabolomic data for system-level understanding.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is small (53.3 KB), indicating limited scope or a summary of results.

Provenance

Source

figshare

Collection Method

Experimental data from zebrafish studies involving cardiac morphology, function, transcriptome, and metabolome analysis.

Time Range

Study period not specified; dataset published in April 2026.

Freshness

Last updated 2026-04-14 17:43:29; freshness should be verified.

Geography

Geographic coverage of the study is not specified.