Multiomics Analysis of Bioactive Peptide BP1 in Zebrafish Cardiomyopathy Models

A 533.0 KB Excel dataset from figshare by Shweta Thakur, last updated in April 2026. It contains transcriptomic and metabolomic data from zebrafish larvae and adult models used to study the cardioprotective effects of a novel bioactive peptide (BP1). Results indicate BP1 treatment significantly reduced cardiac dysfunction induced by isoproterenol and doxorubicin.

Use Cases

• Identify gene expression changes associated with cardiotoxicity based on transcriptomic data mentioned in the description
• Analyze metabolic pathway alterations (e.g., sphingolipid, glutathione metabolism) based on untargeted metabolomics results
• Model the cardioprotective effects of bioactive peptides based on cardiac morphology and functional parameter measurements
• Perform weighted gene co-expression network analysis (WGCNA) based on the described transcriptomic data

Strengths

• Dataset is 533.0 KB in size, making it quick to download and inspect.
• Includes multiomics data (transcriptome and metabolome) for a systems-level analysis.
• Results are based on both zebrafish larvae and adult models, providing developmental stage context.
• License is CC-BY-NC-4.0, permitting non-commercial reuse with attribution.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is specific to a zebrafish model, limiting direct applicability to human studies.

Provenance

Source

figshare

Collection Method

Experimental data from zebrafish models treated with isoproterenol (ISO) and doxorubicin (DOX), followed by transcriptomic and metabolomic analysis.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-04-14 17:43:31; freshness should be verified.

Geography

Laboratory study; geographic origin not specified.