Murine microenvironment metaprofiles associate with human cancer etiology and intrinsic su

NASA provides gene expression data from a mouse model studying radiation effects on tumor biology. The dataset includes total RNA from 56 p53null mammary tumors derived from transplantations into irradiated or sham-irradiated hosts. The data was last updated on March 13, 2026.

Use Cases

• Identifying gene expression signatures associated with radiation exposure in tumor hosts.
• Discriminating between radiation-preceded and sporadic human thyroid cancers based on ortholog metaprofiles.
• Associating host irradiation metaprofiles with estrogen receptor negative and basal-like breast cancer subtypes.
• Analyzing the role of inflammation and TGFB levels in claudin-low tumor subtypes.

Strengths

• Data is derived from a controlled experimental model with 56 total tumor samples.
• Specific sample counts are provided: 32 tumors from irradiated wild-type mice and 24 from irradiated TGFb1 heterozygote hosts.
• Analysis shows strong associations with established human cancer subtypes like basal-like and claudin-low breast cancer.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data format is listed as BIN, which may require specialized tools for access and analysis.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Total RNA extraction from mammary tumors in a controlled mouse transplantation model.

Time Range

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Freshness

Last updated 2026-03-13 19:15:04.849872; freshness should be verified.

Geography

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