Mycobacterium tuberculosis Androgen and Estrogen Synthesis from Steroid Precursors

Rogelio Hernandez Pando authored this dataset on the metabolic conversion of steroid precursors by Mycobacterium tuberculosis. The data likely contains results from incubating the H37Rv reference strain with tritiated progesterone, androstenedione, testosterone, and dehydroepiandrosterone, analyzing the synthesized androgens and estrogens. The dataset was last updated on 2026-05-01.

Use Cases

• Modeling bacterial steroidogenic pathways based on the described conversion of progesterone to androstenedione and testosterone.
• Investigating the role of 3β-hydroxysteroid dehydrogenase in Mycobacterium tuberculosis based on the synthesis of androstenedione from DHEA.
• Analyzing potential sex hormone influence on tuberculosis disease progression based on the synthesis of estradiol and estrone.
• Comparing steroid metabolism between pathogenic and non-pathogenic mycobacteria based on the reference to Mycobacterium smegmatis.

Strengths

• Specific experimental details are provided, including the use of the H37Rv reference strain and incubation conditions.
• The dataset is associated with a clear, CC-BY-4.0 license for open use.
• The 118.7 KB file size suggests a focused, manageable dataset for analysis.

Limitations

• Row count and column-level documentation are unknown, requiring manual inspection after download.
• The dataset's 118.7 KB size indicates a very limited scope, likely containing summary experimental results rather than raw high-throughput data.

Provenance

Source

figshare, author Rogelio Hernandez Pando.

Collection Method

Experimental data from incubating Mycobacterium tuberculosis H37Rv with tritiated steroid precursors and analyzing products via thin layer chromatography.

Freshness

Last updated 2026-05-01 19:17:34; freshness should be verified.